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Publications

Research papers, reviews, chapters and conference publications

Research by Franco Cortese and Arkadi Prokopov, presented in a single curated sequence with full citations, complete author lists and concise institutional affiliations.

Journal articles Book chapters Conference work
Latest publication

New Space Medicine Scientific Article Preprint (September 2026)

The Biogerontology Research Foundation and Oxy Wave Foundation lead a 16-author international collaboration, with co-authors from NASA Johnson Space Center, Cedars-Sinai and the Broad Institute, proposing controlled hypoxic habitats as a core part of radiation protection for deep-space crews.

The sixteen co-authors of the preprint Radiation Countermeasures for Deep-Space Exploration, shown with their photographs, names, institutional affiliations and institution logos.

Radiation Countermeasures for Deep-Space Exploration: An Integrated Hypoxic Radioprotection Framework. Posted on Preprints.org on 14 September 2026; not yet peer-reviewed.

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Publications

Selected research and reference works

Franco Cortese2018JOURNAL REVIEW

Vive la radiorésistance!: Converging Research in Radiobiology and Biogerontology to Enhance Human Radioresistance for Deep Space Exploration and Colonization

Cortese F, Klokov D, Osipov A, et al. Vive la radiorésistance!: Converging Research in Radiobiology and Biogerontology to Enhance Human Radioresistance for Deep Space Exploration and Colonization. Oncotarget. 2018;9:14692-14722. doi:10.18632/oncotarget.24461.

Authors

Franco Cortese; Dmitry Klokov; Andreyan Osipov; Jakub Stefaniak; Alexey Moskalev; Jane Schastnaya; Charles Cantor; Alexander Aliper; Polina Mamoshina; Igor Ushakov; Alex Sapetsky; Quentin Vanhaelen; Irina Alchinova; Mikhail Karganov; Olga Kovalchuk; Ruth Wilkins; Andrey Shtemberg; Marjan Moreels; Sarah Baatout; Evgeny Izumchenko; João Pedro de Magalhães; Artem V. Artemov; Sylvain V. Costes; Afshin Beheshti; Xiao Wen Mao; Michael J. Pecaut; Dmitry Kaminskiy; Ivan V. Ozerov; Morten Scheibye-Knudsen; Alex Zhavoronkov

Affiliations

Biogerontology Research Foundation; Department of Biomedical and Molecular Sciences, Queen’s University School of Medicine, Queen’s University; Canadian Nuclear Laboratories; Department of Biochemistry, Microbiology and Immunology, University of Ottawa; State Research Center – Burnasyan Federal Medical Biophysical Center, Federal Medical Biological Agency; Moscow Institute of Physics and Technology; Nuffield Department of Medicine, Target Discovery Institute, University of Oxford; Laboratory of Molecular Radiobiology and Gerontology, Institute of Biology, Komi Science Center, Ural Branch of the Russian Academy of Sciences; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences; Department of Biomedical Engineering, Boston University; Laboratory of Bioinformatics, D. Rogachev Federal Medical Research Center of Pediatric Hematology, Oncology and Immunology; Department of Computer Science, University of Oxford; Laboratory of Physicochemical and Ecological Pathophysiology, Institute of General Pathology and Pathophysiology; Research Institute for Space Medicine, Federal Medical Biological Agency; Canada Cancer and Aging Research Laboratories; University of Lethbridge; Environmental and Radiation Health Sciences Directorate, Health Canada; Laboratory of Extreme Physiology, Institute of Medical and Biological Problems, Russian Academy of Sciences; Radiobiology Unit, Interdisciplinary Biosciences, Belgian Nuclear Research Centre; Department of Molecular Biotechnology, Ghent University; Department of Otolaryngology – Head and Neck Surgery, Johns Hopkins University School of Medicine; Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool; NASA Ames Research Center; Space Biosciences Division, Wyle Laboratories, NASA Ames Research Center; Division of Hematology/Oncology, Molecular Oncology Research Institute, Tufts Medical Center; Division of Biomedical Engineering Sciences, Loma Linda University; Deep Knowledge Life Sciences; Center for Healthy Aging, University of Copenhagen.

Affiliation logos
BGRFQueen’s UniversityUniversity of OxfordNASABoston UniversityUniversity of LiverpoolBelgian Nuclear Research CentreUniversity of Copenhagen+20 institutions
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Franco Cortese2019JOURNAL ARTICLE

Blood Biochemistry Analysis to Detect Smoking Status and Quantify Accelerated Aging in Smokers

Mamoshina P, Kochetov K, Cortese F, Kovalchuk A, Aliper A, Lane E, Scheibye-Knudsen M, Cantor CR, Skjodt NM, Kovalchuk O, Zhavoronkov A. Blood Biochemistry Analysis to Detect Smoking Status and Quantify Accelerated Aging in Smokers. Scientific Reports. 2019;9:142. doi:10.1038/s41598-018-35704-w.

Authors

Polina Mamoshina; Kirill Kochetov; Franco Cortese; Anna Kovalchuk; Alexander Aliper; Eugene Lane; Morten Scheibye-Knudsen; Charles R. Cantor; Neil M. Skjodt; Olga Kovalchuk; Alex Zhavoronkov

Affiliations

Canada Cancer and Aging Research Laboratories; Department of Computer Science, University of Oxford; Computer Technologies Laboratory, ITMO University; Research Department, Biogerontology Research Foundation; Canadian Longevity Alliance; University of Lethbridge; Leaders in Medicine Program, Cumming School of Medicine, University of Calgary; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen; Department of Biomedical Engineering, Boston University; Buck Institute for Research on Aging.

Affiliation logos
BGRFUniversity of OxfordITMO UniversityUniversity of LethbridgeUniversity of CalgaryUniversity of CopenhagenBoston UniversityBuck Institute+2 institutions
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Arkadi Prokopov2012BOOK CHAPTER

Intermittent Hypoxia and Health: From Evolutionary Aspects to Mitochondria Rejuvenation

Prokopov AF. Intermittent Hypoxia and Health: From Evolutionary Aspects to Mitochondria Rejuvenation. In: Xi L, Serebrovskaya TV, eds. Intermittent Hypoxia and Human Diseases. London: Springer; 2012. Chapter 21. doi:10.1007/978-1-4471-2906-6_21.

Authors

Arkadi F. Prokopov

Affiliations

La Balance Clinic.

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Franco Cortese2018JOURNAL ARTICLE

Population-Specific Biomarkers of Human Aging: A Big Data Study Using South Korean, Canadian, and Eastern European Patient Populations

Mamoshina P, Kochetov K, Lane E, Cortese F, Aliper A, Lee WS, Ahn SM, Uhn L, Skjodt NM, Kovalchuk O, Scheibye-Knudsen M, Zhavoronkov A. Population-Specific Biomarkers of Human Aging: A Big Data Study Using South Korean, Canadian, and Eastern European Patient Populations. The Journals of Gerontology: Series A. 2018;73(11):1482-1490. doi:10.1093/gerona/gly005.

Authors

Polina Mamoshina; Kirill Kochetov; Eugene Lane; Franco Cortese; Alexander Aliper; Won-Suk Lee; Sung-Min Ahn; Lee Uhn; Neil M. Skjodt; Olga Kovalchuk; Morten Scheibye-Knudsen; Alex Zhavoronkov

Affiliations

Department of Computer Science, University of Oxford; Computer Technologies Laboratory, ITMO University; Department of Biomedical and Molecular Sciences, Queen’s University School of Medicine; Biogerontology Research Foundation; Canadian Longevity Alliance; Gachon University Gil Medical Center; Canada Cancer and Aging Research Laboratories; University of Lethbridge; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen.

Affiliation logos
University of OxfordITMO UniversityQueen’s UniversityBGRFGachon UniversityUniversity of LethbridgeUniversity of Copenhagen+2 institutions
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Arkadi Prokopov2007JOURNAL ARTICLE

Theoretical Paper: Exploring Overlooked Natural Mitochondria-Rejuvenative Intervention: The Puzzle of Bowhead Whales and Naked Mole Rats

Prokopov AF. Theoretical Paper: Exploring Overlooked Natural Mitochondria-Rejuvenative Intervention: The Puzzle of Bowhead Whales and Naked Mole Rats. Rejuvenation Research. 2007;10(4):543-559. doi:10.1089/rej.2007.0546.

Authors

Arkadi F. Prokopov

Affiliations

Physician for Integrative Medicine.

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Franco Cortese2020JOURNAL REVIEW

Aging Fits the Disease Criteria of the International Classification of Diseases

Khaltourina D, Matveyev Y, Alekseev A, Cortese F, Ioviță A. Aging Fits the Disease Criteria of the International Classification of Diseases. Mechanisms of Ageing and Development. 2020;189:111230. doi:10.1016/j.mad.2020.111230.

Authors

Daria Khaltourina; Yuri Matveyev; Aleksey Alekseev; Franco Cortese; Anca Ioviță

Affiliations

Department of Risk Factor Prevention, Federal Research Institute for Health Organization and Informatics; International Longevity Alliance; Research Laboratory, Moscow Regional Research and Clinical Institute; Faculty of Physics, Lomonosov Moscow State University; Biogerontology Research Foundation.

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Arkadi Prokopov2010JOURNAL ARTICLE

A Case of Recovery From Dementia Following Rejuvenative Treatment

Prokopov AF. A Case of Recovery From Dementia Following Rejuvenative Treatment. Rejuvenation Research. 2010;13(2-3):217-219. doi:10.1089/rej.2009.0947.

Authors

Arkadi F. Prokopov

Affiliations

Son Baulo Medical Center.

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Franco Cortese2024BOOK CHAPTER

Policies for Healthy Longevity

Stambler I, Young S, Kaminskiy D, Inkster I, Cortese F, Olshansky SJ. Policies for Healthy Longevity. In: Trukhanov A, Chan MKS, eds. Nalapko Y, associate ed. ESAAM Handbook on Longevity Medicine: The Road Map. European Wellness Academy; 2024. Chapter 13. doi:10.69669/CK7298.

Authors

Ilia Stambler; Sergey Young; Dmitry Kaminskiy; Ian Inkster; Franco Cortese; S. Jay Olshansky

Affiliations

International Longevity Alliance; Longevity Vision Fund; Deep Knowledge Group; Aging Analytics Agency; Biogerontology Research Foundation; School of Public Health, University of Illinois Chicago.

Affiliation logos
International Longevity AllianceLongevity Vision FundDeep Knowledge GroupAging Analytics AgencyBGRFUniversity of Illinois Chicago
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Arkadi Prokopov2010JOURNAL ARTICLE

Affordable Rejuvenation: A Prototype Facility in Action

Prokopov AF, Reinmuth J. Affordable Rejuvenation: A Prototype Facility in Action. Rejuvenation Research. 2010;13(2-3):350-352. doi:10.1089/rej.2009.0946.

Authors

Arkadi F. Prokopov; Juergen Reinmuth

Affiliations

Son Baulo Medical Center.

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Franco Cortese2017JOURNAL REVIEW

Induced Cell Turnover: A Novel Therapeutic Modality for In Situ Tissue Regeneration

Cortese FAB, Aguiar S, Santostasi G. Induced Cell Turnover: A Novel Therapeutic Modality for In Situ Tissue Regeneration. Human Gene Therapy. 2017;28(9):703-716. doi:10.1089/hum.2016.167.

Authors

Francesco Albert Bosco Cortese; Sebastian Aguiar; Giovanni Santostasi

Affiliations

Biogerontology Research Foundation; Department of Biomedical and Molecular Sciences, Queen’s University School of Medicine; Neurobiology Department, Swammerdam Institute for Life Sciences, University of Amsterdam; Department of Neurology, Feinberg School of Medicine, Northwestern University.

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Arkadi Prokopov2020SHORT ARTICLE / EXTENDED ABSTRACT

Utility of Hypoxic Preconditioning in the Treatment of Dementia

Prokopov AF. Utility of Hypoxic Preconditioning in the Treatment of Dementia. Journal of Pediatric Neurological Disorders. 2020;3(2).

Authors

Arkadi F. Prokopov

Affiliations

Athletic HighTech.

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Franco Cortese2017JOURNAL REVIEW

RNAi Mechanisms in Huntington’s Disease Therapy: siRNA versus shRNA

Aguiar S, van der Gaag B, Cortese FAB. RNAi Mechanisms in Huntington’s Disease Therapy: siRNA versus shRNA. Translational Neurodegeneration. 2017;6:30. doi:10.1186/s40035-017-0101-9.

Authors

Sebastian Aguiar; Bram van der Gaag; Francesco Albert Bosco Cortese

Affiliations

Molecular Neuroscience Laboratory, Swammerdam Institute for Life Sciences, University of Amsterdam; Fulbright Program, U.S. Department of State; Department of Neurobiology, Care Sciences and Society, Karolinska Institute; Biogerontology Research Foundation; Department of Biomedical and Molecular Sciences, Queen’s University School of Medicine.

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Arkadi Prokopov2020SHORT ARTICLE / EXTENDED ABSTRACT

Metabolic Neuroimaging Using Direct Current Potential

Prokopov AF. Metabolic Neuroimaging Using Direct Current Potential. Journal of Pediatric Neurological Disorders. 2020;3(2).

Authors

Arkadi F. Prokopov

Affiliations

Athletic HighTech.

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Franco Cortese2017JOURNAL ARTICLE

Towards Natural Mimetics of Metformin and Rapamycin

Aliper A, Jellen L, Cortese F, Artemov A, Karpinsky-Semper D, Moskalev A, Swick AG, Zhavoronkov A. Towards Natural Mimetics of Metformin and Rapamycin. Aging (Albany NY). 2017;9(11):2245-2268. doi:10.18632/aging.101319.

Authors

Alex Aliper; Laura Jellen; Franco Cortese; Artem Artemov; Diana Karpinsky-Semper; Alexey Moskalev; Andrew G. Swick; Alex Zhavoronkov

Affiliations

Biogerontology Research Foundation; Department of Biomedical and Molecular Sciences, Queen’s University School of Medicine; Life Extension; Institute of Biology, Komi Science Center, Ural Branch of the Russian Academy of Sciences.

Affiliation logos
BGRFQueen’s UniversityLife ExtensionKomi Science Center
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Arkadi Prokopov2001CONFERENCE PAPER

Benefits of Modified Breathing Air for Spacecraft and Planetary Habitats

Kotliar I, Prokopov A. Benefits of Modified Breathing Air for Spacecraft and Planetary Habitats. Paper presented at the Fourth International Mars Society Convention; August 23-26, 2001; Stanford University, Stanford, California.

Authors

I. Kotliar; A. Prokopov

Affiliations

Hypoxico.

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Franco Cortese2018JOURNAL ARTICLE

Machine Learning on Human Muscle Transcriptomic Data for Biomarker Discovery and Tissue-Specific Drug Target Identification

Mamoshina P, Volosnikova M, Ozerov IV, Lane E, Skibina E, Cortese F, Zhavoronkov A. Machine Learning on Human Muscle Transcriptomic Data for Biomarker Discovery and Tissue-Specific Drug Target Identification. Frontiers in Genetics. 2018;9:242. doi:10.3389/fgene.2018.00242.

Authors

Polina Mamoshina; Marina Volosnikova; Ivan V. Ozerov; Eugene Lane; Ekaterina Skibina; Franco Cortese; Alex Zhavoronkov

Affiliations

Department of Computer Science, University of Oxford; Computer Technologies Laboratory, ITMO University; Biogerontology Research Foundation; Buck Institute for Research on Aging.

Affiliation logos
University of OxfordITMO UniversityBGRFBuck Institute
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Arkadi Prokopov2008PROFESSIONAL MAGAZINE ARTICLE

Zelluläre Kraftwerke natürlich reparieren: Vitalität durch spezielles Sauerstofftraining

Prokopov AF. Zelluläre Kraftwerke natürlich reparieren: Vitalität durch spezielles Sauerstofftraining. CoMed. 2008;(11):37-38.

Authors

Arkadi F. Prokopov

Affiliations

Independent clinical research in integrative and mitochondrial medicine.

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Franco Cortese2019BOOK CHAPTER

Induced Cell Turnover and the Future of Regenerative Medicine

Stefaniak J, Cortese FAB, Santostasi G. Induced Cell Turnover and the Future of Regenerative Medicine. In: Lee N, ed. The Transhumanism Handbook. Cham: Springer; 2019:413-422. doi:10.1007/978-3-030-16920-6_23.

Authors

Jakub Stefaniak; Francesco Albert Bosco Cortese; Giovanni Santostasi

Affiliations

Nuffield Department of Medicine, University of Oxford; Biogerontology Research Foundation; Department of Biomedical and Molecular Sciences, Queen’s University; Department of Neurology, Feinberg School of Medicine, Northwestern University.

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Franco Cortese2016JOURNAL REVIEW

Whole-Body Induced Cell Turnover: A Proposed Intervention for Age-Related Damage and Associated Pathology

Cortese FAB, Santostasi G. Whole-Body Induced Cell Turnover: A Proposed Intervention for Age-Related Damage and Associated Pathology. Rejuvenation Research. 2016;19(4):322-336. doi:10.1089/rej.2015.1763.

Authors

Francesco Albert Bosco Cortese; Giovanni Santostasi

Affiliations

Research Department, ELPIs Foundation for Indefinite Lifespans; Department of Neurology, Feinberg School of Medicine, Northwestern University.

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Franco Cortese2014CONFERENCE PROCEEDINGS PAPER

The Maximally Distributed Intelligence Explosion

Cortese FAB. The Maximally Distributed Intelligence Explosion. In: Implementing Selves with Safe Motivational Systems and Motivational Systems and Self-Improvement: Papers from the AAAI Spring Symposium. AAAI Technical Report SS-14-03. Palo Alto, CA: AAAI Press; 2014:7-12.

Authors

Francesco Albert Bosco Cortese

Affiliations

Institute for Ethics and Emerging Technologies; ELPIs Foundation for Indefinite Lifespans; Ria University Press; Center for Interdisciplinary Philosophic Studies.

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