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Active research · Veterinary · Translational

Pet rejuvenation trial

Oxygen-modulation interventions in aged dogs and cats

A UAE multi-university veterinary trial of IHHT, HBOT and combination oxygen-modulation interventions — the translational bridge between human longevity medicine and companion-animal care, run with the Oxy Wave Foundation.

• Breed-diverse• Four-arm design• Biological age• Fertility biomarkers

Trial design

A four-arm, breed-diverse design

Each arm runs through the same phase structure, beginning with a sentinel safety cohort before full recruitment.

Sentinel safetyRecruitmentInterventionFollow-up
Arm 1 · IHHTIntermittent hypoxic-hyperoxic training
Arm 1 · IHHT
Arm 2 · HBOTHyperbaric oxygen therapy
Arm 2 · HBOT
Arm 3 · CombinationSequenced oxygen-modulation
Arm 3 · Combination
Arm 4 · ControlStandard veterinary care
Arm 4 · Control

Measurement

Biomarker architecture

Age
Biological age
markers
Fn
Healthspan and
function
Rep
Reproductive
biomarkers
Infl
Inflammation and
metabolism

The trial measures biological-age, healthspan and fertility biomarkers across breed-diverse cohorts, with de-identified analytics outputs available to university partners for sub-study analysis.

For university partners

What a partner receives

What partners receive

  • Funding support for site execution, sample processing and trial operations
  • Co-development role in a publishable UAE-first veterinary longevity programme
  • Access to protocol templates, safety SOPs and biomarker architecture
  • Lead breed-specific, biomarker, reproduction or One Health sub-studies

Proposed next steps

  • Twenty-minute scoping call with the PI, dean or research office
  • Exchange of protocol synopsis and site feasibility checklist
  • Ethics pre-consultation and sentinel safety cohort
  • Draft MoU: funding, data governance, publication rights, animal welfare

Translational value

Why this matters beyond veterinary care

Companion animals

  • Natural ageing
  • Shared environment
  • Breed-specific risk
  • Compressed lifespan
Oxygen modulation

Human longevity

  • Biological age markers
  • Healthspan protocols
  • Fertility outcomes
  • Clinical translation

A bridge, not a detour

Companion-animal longevity is an underdeveloped translational bridge between human longevity medicine and veterinary care. Compressed lifespans allow outcomes to be observed on a research-practical timescale.

Trial phases

From sentinel safety to publication

Phase
0
Sentinel safetyA small cohort establishes the safety envelope
Phase
1
RecruitmentBreed-diverse cohorts enrolled across sites
Phase
2
InterventionFour arms run in parallel under common SOPs
Phase
3
AnalysisBiomarker readout and sub-study analysis
Phase
4
PublicationUAE-first veterinary longevity programme

Standards

Welfare, governance and data

♢

Animal welfare

Sentinel safety cohort before full recruitment, with welfare standards written into every site MoU.

Ethics pre-consultationStop rules at site level
▣

Data governance

De-identified analytics outputs, defined publication rights and shared protocol templates.

Central protocol templatesAgreed publication rights
▦

Multi-site design

Common SOPs across university sites, allowing breed and regional sub-studies.

Site feasibility checklistCommon safety SOPs