Chronic Lyme
Mitochondrial dysfunction underlying persistent symptoms.
● Science · Lead Priority
IHHT, IHT & HBOT
research Devices · Protocols · Their compositions
The Foundation's lead scientific priority: comprehensive research into intermittent hypoxic-hyperoxic training devices and protocols, with dedicated testing of machines and protocols against a validated evidence base.
● Mitochondrial hormesis● H5I2T● Clinician co-pilot● Comparative vs HBOT
● The Mechanism
From controlled oxygen to cellular adaptation
♨1
Controlled stress
Oxygen and CO₂ modulated in cycles
◉2
HIF-1α signalling
Hypoxia-inducible response activated
◎3
Mitochondrial hormesis
Biogenesis and rejuvenation
◈4
Systemic adaptation
Immune, vascular and glymphatic gains
IHHT applies increasing levels of controlled stress by manipulating available oxygen and carbon dioxide. The result is mitochondrial rejuvenation and biogenesis, improved microcapillary health, glymphatic cleaning of the brain, and strengthening of the immune system — the cellular basis of both longevity and the treatment of major metabolic disease.
● Dose & Response
The hormetic window
The same science supports two distinct protocol families: mild amplitudes for treating pathology, and high amplitudes for enhancement and resilience.
Adaptive benefitHormetic stress amplitude →
Two protocol families
- IHHT — mild, therapeutic amplitude used in the management of disease
- H5I2T — hypoxic, hyperoxic, hypercapnic and hypocapnic high-intensity interval training
- Higher hormetic amplitude, focused on neuroenhancement and immune strengthening
- Protocol selection is matched to pathology, goal and current health status
● Comparative Analysis
IHHT measured against hyperbaric oxygen therapy
Hyperbaric therapy dominates the Western market through marketing rather than comparative evidence. Our programme tests that assumption directly.
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| DIMENSION | IHHT | HBOT |
|---|---|---|
| Relative effectiveness | Baseline +20–30% | Baseline |
| Safety & side-effects | No pressurisation | Pressurisation risks |
| Cost & complexity | Lower, simpler | High cost, complex |
| Evidence base | Growing peer-reviewed | Established, widespread |
| Origin | Cosmonaut hypoxic training | Astronaut oxygen programmes |
● Programme Architecture
What we are building
Device research is only one layer. The protocol-personalisation infrastructure is a cornerstone of the programme, not an add-on.
Optimised IHHT machinesDesign, testing and manufacture-readiness
Protocol libraryThousands of variations by pathology and goal
Clinician AI co-pilotProtocol adjustment to patient specifics
Telemedicine layerSpecialist consultation for clinical use
Four layers, one system
The Foundation studies the full stack: the machines themselves, the protocol compositions they run, and the decision infrastructure clinicians need to apply them safely to individual patients.
- Study, testing and optimisation of existing machines
- Advanced high-intensity protocol development
- Comparative analysis against hyperbaric approaches
- Developed with the practitioners who established the original IHHT science
● Evidence Base
A validated scientific foundation
1960s
Original hypoxic training developed through space medicine
1990s
Intermittent hypoxic conditioning enters wider clinical practice
2019
Nobel Prize recognition of cellular oxygen sensing
Today
Applied research, protocol optimisation and validation
● Clinical Translation
Conditions under investigation
Alzheimer’s
disease
Neuroprotection through improved cellular energy.
Type-II diabetes
Metabolic recalibration via hormetic conditioning.
Long COVID
Chronic viral respiratory recovery and immune rebalancing.